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Background
Intrinsic primary afferent neurons (IPANs) enable the gut to manifest reflexes in the absence of CNS input. PKG1α is selectively expressed in a subset of neurons in dorsal root ganglia (DRG) and has been linked to nociception and long‐term hyperexcitability.
Methods
We used immunoblotting, immunocytochemistry, and in vitro assays of IPAN‐dependent enteric functions to test hypotheses...