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Human cardiomyopathy is associated with decreased cardiac Na + channel current (I Na ), and Na + channel changes have been implicated in the increased risk of sudden death in heart failure. We have reported that in cardiomyopathy, elevated intracellular NADH downregulates I Na acutely to a magnitude seen in Brugada syndrome through protein kinase C (PKC) activation...
Elevated NADH downregulates cardiac Na + channel (Na v 1.5) current (I Na ) acutely to a magnitude seen in Brugada syndrome by activating protein kinase C (PKC) and inducing mitochondrial ROS overproduction. Here, we studied the mechanism whereby this kinase alters I Na . HEK293 cells transfected with human cardiac Na v 1.5 wild type (WT), S1503A, and S1503D...
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