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The cyclobis(paraquat-p-phenylene) receptor associates with various phenoxy-substituted guest compounds in water, including phenyl glycopyranosides. The receptor was found to bind phenyl β-D-glucopyranoside 0.6 kcal/mol more strongly than phenyl α-D-glucopyranoside. In addition, there was a general trend of increased affinity for anionic guests compared to structurally related neutral compounds.
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