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This study evaluated the immune response elicited by a Ub‐fused Ag85A DNA vaccine against Mycobacterium tuberculosis. BALB/c mice were vaccinated with plasmid DNA encoding Ag85A protein, Ub‐fused Ag85A DNA vaccine (UbGR‐Ag85A) and negative DNA vaccines, respectively. Ag85A DNA vaccine immunization induced a Thl‐polarized immune response. The production of Thl‐type cytokine (IFN‐γ) and proliferative...
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