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Introduction: To study the T cell response to aerosolised antigens entering the lung we have used an ovalbumin specific T cell receptor (TCR) transgenic mouse DO.11.10. The TCR transgenes are expressed in BALB/c mice (H-2d haplotype) which facilitates the aerosol challenge of transgenic mice directly. The principle advantages of adopting this approach are that the magnitude of T cell response is...
Introduction: Allergic asthma is characterized by infiltration of activated Th2 cells and eosinophils into the airways. Th2 cells are important mediators of allergic inflammatory responses as they secrete cytokines that promote the differentiation and activation of eosinophils and the induction of IgE synthesis. We have used a TCR transgenic mouse to study of inflammatory responses in the lung after...
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