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Chk1 inhibition increases cell sensitivity to both chemotherapy and radiotherapy in several tumour types and is, therefore, a promising anti-cancer approach. Although several Chk1 inhibitors have been developed, their clinical progress has been hampered by low bioavailability and off-target toxicities.We characterized the radiosensitizing activity of CCT244747, the first orally bioavailable Chk1 inhibitor...
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