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Background
Studies on early puberty and incident asthma have reported inconsistent results and are mainly performed in females. In this longitudinal study, we investigated the causal relationship between pubertal maturation and asthma through Mendelian randomization (MR) and explored the joint effect of overweightness and early pubertal maturation on asthma.
Methods
We used data from the Taiwan...
Background
Childhood asthma comprises different phenotypes with complex pathophysiology. Different asthma phenotypes evoke various clinical symptoms and vary in their responses to treatments.
Methods
We applied k‐means clustering algorithm of twelve objective laboratory tests among 351 asthmatic children enrolled in the Taiwanese Consortium of Childhood Asthma Study (TCCAS). We constructed gene...
BackgroundPrevious studies have shown the relationship between club cell secretory protein (Clara) (CC‐16) and respiratory diseases. However, few studies have explored the associations between urine CC‐16 levels and environmental tobacco smoke (ETS) exposure in children. The objective of this study was to evaluate whether ETS exposure is associated with CC‐16 when stratified by asthma status.
MethodsIn...
There is growing evidence that multiple genes and air pollutants are associated with asthma. By identifying the effect of air pollution on the general population, the effects of air pollution on childhood asthma can be better understood. We conducted the Taiwan Children Health Study (TCHS) to investigate the influence of gene–air pollution interactions on childhood asthma. Complete monitoring data...
BackgroundExposure to environmental hormones, such as alkylphenols, has been suggested to be associated with the development of asthma, but the mechanism of action remains unclear.
ObjectiveThis study examined the effect of 4‐nonylphenol (NP), one of the most important alkylphenols, on conventional dendritic cells (cDCs) and adaptive T‐cell responses. It also explored the role of aryl hydrocarbon...
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