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We developed a sequence‐specific primer PCR (SSP‐PCR) for detection of a 5·8‐kb deletion (Bm5·8) involving an erythroid cell‐specific regulatory element in intron 1 of the ABO blood group gene. Using this SSP‐PCR, we performed genetic analysis of 382 individuals with Bm or ABm. The 5·8‐kb deletion was found in 380 individuals, and disruption of the GATA motif in the regulatory element was found in...
Background and ObjectivesPreviously, a weak phenotype Am or Bm was assumed to be caused by a reduction of A or B gene expression in bone marrow cells, but not in mucus‐secreting cells. However, ABO expression has not been examined in erythroid progenitor cells of Am or Bm individuals.
Materials and MethodsWe carried out in vitro erythroid differentiation of CD34+ cells from peripheral blood of a...
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