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Described here is a method for the measurement of the radio‐metabolites of the positron emission tomography radiotracer [6‐O‐methyl‐11C]diprenorphine ([11C]diprenorphine) using in‐line solid‐phase extraction (SPE) combined with radio‐high‐pressure liquid chromatography analysis. We believe that this method offers a reliable and reproducible approach to [11C]diprenorphine metabolite analysis. In addition,...
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