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The receptor binding domain (RBD) of the SARS‐CoV‐2 Spike (S) glycoprotein is an appealing immunogen, but associated vaccine approaches must overcome the hapten‐like nature of the compact protein and adapt to emerging variants with evolving RBD sequences. Here, a vaccine manufacturing methodology is proposed comprising a sterile‐filtered freeze‐dried lipid cake formulation that can be reconstituted...