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Abstract. We have compared the effect of bradykinin (BK) and the nonpeptide kinin B2 receptor agonist, FR 190997, in producing changes in membrane potential and tension in the circular muscle of guinea-pig colon by the sucrose gap technique. In the presence of atropine (1M), S-ketoprofen (3M) and apamin (0.1M), BK (1M for 20s) induced a transient depolarization of the membrane with superimposed action...
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