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The synthesis and pharmacological characterization of a novel furan-based class of voltage-gated sodium channel blockers is reported. Compounds were evaluated for their ability to block the tetrodotoxin-resistant sodium channel Na v 1.8 (PN3) as well as the Na v 1.2 and Na v 1.5 subtypes. Benchmark compounds from this series possessed enhanced potency, oral bioavailability,...
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