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We have studied the cellular responses to simvastatin (S) and atorvastatin (A), two of the most potent HMG-CoA reductase inhibitors that have been used in humans. The two drugs exhibited similar IC 50 's for inhibition of HMG-CoA reductase from either rat or human, and single oral dosing in rats showed the compounds to be nearly equipotent at inhibiting the incorporation of labeled acetate...
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