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The ability of non-competitive NMDA antagonists and other selected compounds to inhibit [ 3 H]MK-801 binding to the NMDA receptor in brain membranes was evaluated in female, dark Agouti rats. In homologous competition binding studies the average apparent affinity (K d ) of [ 3 H]MK-801 for its binding site was 5.5 nM and the binding site density (B max ) was...
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