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Primary myelofibrosis (PMF) is characterized by leukoerythroblastic anemia with circulating immature myeloid cells, including CD34+ cells, progressive splenomegaly and accumulation of connective tissue and neoangiogenesis in the bone marrow. Altered bone marrow stroma and cell adherence account for the egress of CD34+ cells from the bone marrow. Carcinoembryonic antigen-related cell adhesion molecule...
Gene expression profiling studies have unraveled deregulation of several genes that might be of pathogenetic importance for the development and phenotype of the Philadelphia‐negative chronic myeloproliferative neoplasms. In the context of interferon‐alpha2 as a promising therapeutic agent, we focused upon the transcriptional profiling of interferon‐associated genes in patients with essential thrombocythemia...
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