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Research was conducted to determine the kinetics of hepatic vitellogenin (VTG) mRNA regulation and plasma VTG accumulation and clearance in male sheepshead minnows (Cyprinodon variegatus) during and after cessation of exposure to either 17β-estradiol (E2) or para-nonylphenol (NP). Adult fish were continuously exposed to aqueous measured concentrations of 0.089 and 0.71 μg E2 per l, and 5.6 and 59...
Vitellogenin, the egg yolk precursor protein, has become a popular biomarker for measuring exposure of oviparous animals to estrogen or estrogen mimics. Vitellogenin is normally produced by females in response to normal cycles of estradiol during oogenesis. The gene for vitellogenin is also present in the livers of males but it is normally silent. Upon exposure to estrogen or to an estrogen mimic,...
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