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A series of novel mono- and disubstituted p-tert-butylcalix[4]arene derivatives functionalized with gamma-aminobutyric acid (GABA) and its methyl ester were synthesized and screened in vivo for anticonvulsant activity by determining the minimum effective doses of pentylenetetrazole inducing clonic-tonic convulsions and tonic extension. Calixarene derivative X with one acetic acid and one GABA ester...
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