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Jaundice is a common presentation in medical and surgical gastroenterology practice. Knowledge of the physiology of bilirubin metabolism will help the clinician to understand the mechanisms of development of jaundice. This along with clinical evaluation, laboratory investigation and non-invasive imaging will help when making a firm diagnosis. Further management may require advanced imaging and/or...
Background/Aim: Due to an absence of specific markers, the diagnosis of drug-induced hepatotoxicity is necessarily based on circumstantial evidence and is often inaccurate. We have evaluated the use of the clinical diagnostic scale (CDS) in the causality assessment of hepatotoxic adverse drug reaction (ADR) reports.Methods: 135 hepatic adverse ADRs reported to the Committee on Safety of Medicines...
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