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Idiosyncratic or type B reactions are characterised by their unpredictability and lack of simple dose-dependency. They occur in a small proportion of patients, and usually the predisposing factors are unknown. A proportion of, but not all, idiosyncratic reactions are immune-mediated. Our understanding of immune-mediated reactions is based on the hapten hypothesis, which requires drug bioactivation,...
Idiosyncratic drug toxicity is a major complication of drug therapy and drug development. Such adverse drug reactions (ADRs) include anaphylaxis, blood dyscrasias, hepatotoxicity and severe cutaneous reactions. They are usually serious and can be fatal. At present, prediction of idiosyncratic ADRs at the preclinical stage of drug development is not possible because there are no suitable animal models...
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