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The central challenge in post-genomic era is to characterize the biological functions of newly discovered proteins. Sequence similarity based approaches infer protein functions based on the homology between proteins. We present the similarity relationship between protein sequences and their functions for mouse (Mus musculus) proteome in the context of gene ontology (GO) slim. The similarity between...
The underlying assumption of many automated sequence annotation methods is that similar sequences imply similar biological functions. The present paper re-examines this assumption. A novel measure based on a set of local BLAST alignments is introduced to define the overall similarity between two protein sequences. The relationships between yeast protein sequences and their biological functions in...
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