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Allogeneic hematopoietic cell transplant (HCT) recipients are at risk for herpes simplex virus (HSV) and varicella‐zoster virus (VZV) infections. Routine prophylaxis with acyclovir is recommended during periods of immunosuppression. Brincidofovir (BCV, CMX001), a lipid conjugate of cidofovir, has shown in vitro activity against HSV/VZV, but has not been formally studied for HSV/VZV prophylaxis. We...
Background
Cytomegalovirus (CMV) viremia after CD34+‐selected hematopoietic stem cell transplant (HCT) often requires prolonged antiviral therapy. We report rates and outcomes of resistant CMV in a contemporary cohort of CD34+‐selected HCT recipients managed preemptively.
Methods
We retrospectively reviewed 220 consecutive, CMV‐seropositive recipients (R+), who received CD34+‐selected HCT at Memorial...
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