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Resistance of pancreatic ductal adenocarcinoma (PDAC) to radiotherapy and chemotherapy represents a significant clinical issue. Although the mechanisms of resistance are multi‐faceted, client proteins of heat shock protein 90 (HSP90) such as hypoxia induced factor‐1α (HIF‐1α) have a central role in this process. The purpose of this investigation was to evaluate inhibition of HSP90 as a therapeutic...
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