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In the most commonly occurring form of scoliosis in clinical practice, adolescent idiopathic scoliosis, there is no apparent malformation of the vertebrae. The process of segmentation that gives rise to somites, followed by resegmentation giving rise to vertebrae, and the subsequent formation of the vertebrae all appear normal. Abnormal formation of the vertebrae, for example, in some of the skeletal...
In recent years molecular genetics has revolutionized the study of somitogenesis in developmental biology and advances that have taken place in animal models have been applied successfully to human disease. Abnormal segmentation in man is a relatively common birth defect and advances in understanding have come through the study of cases clustered in families using DNA linkage analysis and candidate...
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