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The histamine H 3 receptor is predominantly expressed in the central nervous system and plays a role in diverse physiological mechanisms. In the present study, the effects of GSK189254, a potent and selective H 3 antagonist, were characterized in preclinical pain models in rats. Systemic GSK189254 produced dose-dependent efficacy (ED 50 =0.77mg/kg i.p.) in a rat model of monoiodoacetate...
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