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The effect of the administration of pertussis toxin as well as modulators of different subtypes of K + channels on the antinociception induced by the H 1 -antihistamines pyrilamine, diphenhydramine and promethazine was evaluated in the mouse hot plate test. Pretreatment with pertussis toxin (0.25 μg/mouse i.c.v.) prevented pyrilamine, diphenhydramine and promethazine antinociception...
The effect produced by repeated administration of the H 1 -antihistaminics diphenhydramine, promethazine and pyrilamine on their ability to induce antinociception was evaluated in the mouse hot-plate and abdominal constriction tests. Contrary to morphine, baclofen and oxotremorine, the three H 1 antagonists investigated did not promote the development of tolerance to the analgesic...
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