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The cellular events involved in acetyl-l-carnitine (ALCAR) analgesia were investigated in the mouse hot plate test. I.c.v. pretreatment with aODNs against the α subunit of G q and G 11 proteins prevented the analgesia induced by ALCAR (100 mg kg -1 s.c. twice daily for 7 days). Administration of the phospholipase C (PLC) inhibitors U-73122 and neomycin, as well as...
The supraspinal cellular events involved in H 1 -mediated hyperalgesia were investigated in a condition of acute thermal pain by means of the mouse hot-plate test. I.c.v. administration of the phospholipase C (PLC) inhibitors U-73122 and neomycin antagonized the hyperalgesia induced by the selective H 1 agonist FMPH. By contrast, U-73343, an analogue of U-73122 used as negative control,...
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