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We recently reported that the oligosomatostatin receptor agonist, ODT8-SST increases food intake in rats via the somatostatin 2 receptor (sst 2 ). We characterized ingestive behavior following intracerebroventricular (icv) injection of a selective sst 2 agonist in freely fed mice during the light phase. The sst 2 agonist (0.01, 0.03, 0.1, 0.3 or 1μg/mouse) injected icv under...
The role of somatostatin in galanin-induced inhibition of gastric acid secretion in urethane-anesthetized mice was investigated by using immunoneutralization of endogenous somatostatin and somatostatin receptor type 2 (SSTR2) knockout mice. Intravenous galanin (10 and 20μg/kg/h) inhibited pentagastrin-stimulated gastric acid secretion by 47 and 33%, respectively. Somatostatin antibody injected i.v...
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