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Background To improve understanding of aspirin hypersensitivity, this study focused on adenosine as a noncyclooxygenase target molecule of aspirin. Adenosine may affect the release of histamine from cutaneous mast cells through a mechanism mediated by the adenosine A3 receptor.
Objectives To investigate the genetic contribution of adenosine A3 receptor gene (ADORA3) polymorphisms in the pathogenesis...
To cite this article: Moon H‐G, Tae Y‐M, Kim Y‐S, Gyu Jeon S, Oh S‐Y, Song Gho Y, Zhu Z, Kim Y‐K. Conversion of Th17‐type into Th2‐type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. Allergy 2010; 65: 1093–1103.
AbstractBackground: Allergen‐specific T‐cell responses orchestrate airway inflammation, which is a characteristic of asthma. Recent evidence suggests...
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