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BackgroundChronic rhinosinusitis (CRS) is an inflammatory process in the nasal cavity and paranasal sinuses, and bacteria have been considered to be a cause. Indeed, recent evidence indicates that bacteria‐derived extracellular vesicles (EV) appear to be an important causative agent of inflammatory diseases. Here, we aimed to evaluate the diversity of nasal microbiota and their secreted EV in patients...
BackgroundRecent evidence indicates that TNF‐α is a key mediator of the development of dsRNA‐enhanced Th2 cell response to inhaled allergens. Natural killer T (NKT) cells may be a candidate source of Th2‐polarizing cytokines.
ObjectiveThe objective of this study was to evaluate the role of lung NKT cells on the development of TNF‐α‐mediated Th2 cell response.
MethodsA virus‐associated asthma mouse...
BackgroundRecent evidence indicates that Staphylococcus aureus, one of the most important human pathogens, secretes vesicles into the extracellular milieu.
ObjectiveTo evaluate whether inhalation of S. aureus‐derived extracellular vesicles (EV) is causally related to the pathogenesis of inflammatory pulmonary diseases.
MethodsStaphylococcus aureus EV were prepared by sequential ultrafiltration and...
BackgroundViral pathogen–associated molecular patterns, such as dsRNA, disrupt airway tolerance to inhaled allergens. Specifically, the Th2 and Th17 cell responses are induced by low‐dose dsRNA and the Th1‐dominant response by high‐dose dsRNA.
ObjectiveIn this model, we evaluate the role of TNF‐α in the development of adaptive immune dysfunction to inhaled allergens induced by airway sensitization...
To cite this article: Hong S‐W, Kim M‐R, Lee E‐Y, Kim JH, Kim Y‐S, Jeon SG, Yang J‐M, Lee B‐J, Pyun B‐Y, Gho YS, Kim Y‐K. Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis‐like skin inflammation. Allergy 2011; 66: 351–359.
AbstractBackground: Recently, we found that Staphylococcus aureus produces extracellular vesicles (EV) that contain pathogenic proteins. Although...
To cite this article: Shin T‐S, Kim JH, Kim Y‐S, Jeon SG, Zhu Z, Gho YS, Kim Y‐K. Extracellular vesicles are key intercellular mediators in the development of immune dysfunction to allergens in the airways. Allergy 2010; 65: 1256–1265.
AbstractBackground: Previous evidence indicates that inhalation of lipopolysaccharide (LPS)‐containing with allergens induced mixed Th1 and Th17 cell responses in...
To cite this article: Choi J‐P, Kim Y‐S, Tae Y‐M, Choi E‐J, Hong B‐S, Jeon SG, Gho YS, Zhu Z, Kim Y‐K. A viral PAMP double‐stranded RNA induces allergen‐specific Th17 cell response in the airways which is dependent on VEGF and IL‐6. Allergy 2010; 65: 1322–1330.
AbstractBackground: Innate immune response by a viral pathogen‐associated molecular pattern dsRNA modulates the subsequent development of...
To cite this article: Moon H‐G, Tae Y‐M, Kim Y‐S, Gyu Jeon S, Oh S‐Y, Song Gho Y, Zhu Z, Kim Y‐K. Conversion of Th17‐type into Th2‐type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. Allergy 2010; 65: 1093–1103.
AbstractBackground: Allergen‐specific T‐cell responses orchestrate airway inflammation, which is a characteristic of asthma. Recent evidence suggests...
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