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Objective
Isopeptide bonds form cross‐links between constituent proteins in the horny layer of the epidermis. Corneodesmosin (CDSN) is a major component of corneodesmosomes, which bind corneocytes together. Both play important roles in maintaining epidermal barrier functions. In the present study, we investigated the expressions of isopeptide bonds, CDSN, and related enzymes in middle ear cholesteatoma...
ObjectiveWe investigated the electrical impedance of and the expressions of tight junction molecules in the cholesteatoma epithelium to provide supporting evidence for the acid lysis theory of bone resorption in middle ear cholesteatoma.
MethodsStudy subjects were patients with primary acquired middle ear cholesteatoma and those with non‐cholesteatomatous chronic otitis media who underwent tympanomastoidectomy...
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