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The immobilized artificial membrane phosphatidylcholine (IAMPC) chromatography was evaluated for the predictability of oral absorption potential of 40 structurally unrelated drugs. The chromatographic capacity factors (kIAM) were determined as a function the pH and composition of the mobile phase, and were corrected for the molar volume of the solutes (kIAM/MWn). The correlation between kIAM/MW...
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