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AbstractAims/hypothesis. N-(carboxymethyl)lysine (CML) is one of the end products of protein glycoxidation and its accumulation is associated with diabetes complications. Since CML-modified proteins are immunogenic, we have investigated the presence of anti-CML antibodies in diabetic patients.Methods. Antibodies against CML-modified human serum albumin (HSA) were measured by direct enzyme-linked immunosorbent...
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