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Cyclophosphamide and cisplatin, while extremely effective in killing tumor cells, are both highly mutagenic and carcinogenic to normal cells. When administered at doses ranging from 50 to 200mg/kg to C3H mice, cyclophosphamide induced mutations at the hprt locus in splenocytes in a linear dose response manner, e.g., mutant frequency increased from 1.5×10 −6 to 4×10 −5 . Under similar...
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