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The effects of liposome-encapsulated hemoglobin (LEH), an artificial oxygen carrier, were experimentally investigated in gerbils in the context of alleviation of hearing loss after transient cochlear ischemia. Animals were randomly assigned to receive 2mL/kg of either LEH (P 50 O 2 =15mmHg) or saline 1h after the experimental induction of 15min of ischemia. Sequential recordings of...
To test liposome‐encapsulated hemoglobin (LEH) in transient cochlear ischemia/reperfusion as a model of sudden deafness, Mongolian gerbils were randomly assigned to receive 2 mL/kg of either low‐affinity LEH (l‐LEH, P50O2 = 40 mm Hg), high‐affinity LEH (h‐LEH, P50O2 = 10 mm Hg), homologous red blood cells (RBCs), or saline (each group n = 6) 30 min before 15‐min occlusion of the bilateral vertebral...
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