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Spontaneous activity of cortical neurons was studied under urethane anesthesia in adult rats 3 months after convulsive status epilepticus induced by lithium-pilocarpine administration at the age of 12 (SE12 group) or 25 (SE25 group) days. Whereas random firing neurons dominated in control animals (61 out of 98 cells), SE25 animals exhibited a significant increase in the incidence of bursting cells...
Rat neocortical slices express spontaneous epileptiform activity after incubation with GABA A receptor blocker bicuculline (BIC, 20 μM), with potassium channel blocker 4-aminopyridine (4-AP, 50 μM) or in Mg 2+ -free medium (LMG). Various parameters of spontaneous and evoked epileptiform discharges and their pharmacological sensitivity were analysed using extracellular field potential...
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