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In neurons of the suprachiasmatic nucleus, spike frequency adaptation and membrane afterhyperpolarization occur during a train of action potentials. Extracellular Ca 2+ may regulate neuronal excitability by several mechanisms, including activation of small conductance and large conductance Ca 2+ -activated K + channels. The overall goal of this study was to examine...
Recent evidence indicates that neuropathic pain from partial peripheral nerve injury is maintained by electrophysiologically abnormal signals from injured sensory neurons. To gain an insight into the mechanisms underlying this electrophysiological abnormality, we examined the effects of S 1 spinal nerve transection on the membrane properties of S 1 dorsal root ganglion neurons one...
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