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Background
Surfactant protein D (SPD) is a member of the collectin family that lines the airway epithelial cells with host defense. However, the role of SPD in the pathogenesis of aspirin‐exacerbated respiratory disease (AERD) is still unclear.
Methods
The serum SPD level was measured in patients with AERD (n = 336), those with aspirin‐tolerant asthma (ATA, n = 442), and healthy controls (HC, n = 104)...
Background
Several studies have demonstrated that allergen‐specific immunotherapy (SIT) can be an effective treatment for atopic dermatitis (AD). However, there is no relevant mouse model to investigate the mechanism and validate the novel modality of SIT in AD.
Methods
NC/Nga mice with induced AD‐like skin lesions received a subcutaneous injection of SIT (an extract of the house dust mite Dermatophagoides farinae...
Background
Clinical presentation of nonsteroidal anti‐inflammatory drugs exacerbated respiratory disease (NERD) is found to be heterogeneous. This study classified phenotypic clusters to determine NERD subtypes.
Methods
We performed two‐step cluster analysis using urticaria, chronic rhinosinusitis (CRS), and atopy, in a NERD cohort comprising 302 patients. Asthma exacerbation was defined as receiving...
BackgroundAtopic dermatitis (AD) is exacerbated by psychological factors, such as stress. We previously reported that corticotrophin‐releasing hormone (CRH) treatment in AD patients decreased the proportion of IL‐10+ Tr1 cells, a subset of inducible regulatory T cells (Tregs). However, changes in the function of Tregs in response to CRH have yet to be studied.
MethodsWe analyzed the total proteins...
Google Trends (GT) is a Web‐based surveillance tool used to explore the searching trends of specific queries on Google. Recent studies have suggested the utility of GT in predicting outbreaks of influenza and other diseases. However, this utility has not been thoroughly evaluated for allergic diseases. Therefore, we investigated the utility of GT for predicting the epidemiology of allergic rhinitis...
To cite this article: Keswani A, Chustz RT, Suh L, Carter R, Peters AT, Tan BK, Chandra R, Kim S‐H, Azam T, Dinarello CA, Kern RC, Schleimer RP, Kato A. Differential expression of interleukin‐32 in chronic rhinosinusitis with and without nasal polyps. Allergy 2012; 67: 25–32.
AbstractBackground: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local inflammation of the upper...
To cite this article: Palikhe NS, Kim S‐H, Cho B‐Y, Ye Y‐M, Choi G‐S, Park H‐S. Genetic variability in CRTH2 polymorphism increases eotaxin‐2 levels in patients with aspirin exacerbated respiratory disease. Allergy 2010; 65: 338–346.
AbstractIntroduction: CRTH2 is expressed on the surface of eosinophils and has been shown to mediate PGD2‐induced eosinophil migration in vitro. Eosinophilic infiltration...
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