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Functional antagonists of the NMDA receptor complex are active in both preclinical behavioral paradigms sensitive to antidepressants (ADs) and in the chronic mild stress (CMS) animal model of depression. Chronic AD treatment induces adaptation of the NMDA receptor complex in naive rodents. Specifically, this adaptation is evident as a reduction in the potency of glycine to displace [ 3 H]5,7-dichlorokynurenic...
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