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Introduction: The non-classical major histocompatibility complex class II molecule HLA-DM has been shown to play a central role in the class II-associated antigen presentation pathway: HLA-DM mediates the release of invariant chain derived CLIP peptides and thereby facilitates loading with antigenic peptides. However, it is not clear whether DM is also able to release naturally processed peptides...
Intracellular antigen processing selects peptides for presentation by human leukocyte antigen (HLA) class I molecules according to unknown rules. To understand the role of the transporters associated with antigen processing (TAP) in peptide selection for presentation by HLA class I molecules, we undertook a comprehensive analysis of the selectivity of human transporter in TAP/peptide binding assays...
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