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Human immunodeficiency virus (HIV)‐1 protease is a known target of CD8+ T cell responses, but it is the only HIV‐1 protein in which no fully characterized HIV‐1 protease CD4 epitopes have been identified to date. We investigated the recognition of HIV‐1 protease by CD4+ T cells from 75 HIV‐1‐infected, protease inhibitor (PI)‐treated patients, using the 5,6‐carboxyfluorescein diacetate succinimidyl...
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