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Focused ultrasound and microbubbles have been shown to locally and noninvasively open the blood-brain barrier. Despite encouraging results in human patients, several performance and safety features, such as poor drug distribution, high drug accumulation along vessels and small sites of red blood cell extravasation, have been unavoidable. We have recently developed a new ultrasound sequence — rapid...
Background
Mesenchymal stem cells (MSCs) have multiple immunomodulatory properties and hold therapeutic potential for inflammatory diseases. However, the therapeutic and immunologic effects of human umbilical cord blood‐derived MSCs (huMSCs) remain largely unexamined for asthma.
Objective
This study was to investigate the immunomodulatory properties of huMSCs in an ovalbumin (OVA)‐induced murine...
The blood-brain barrier (BBB) has been shown capable being opened noninvasively through the combined application of focused ultrasound (FUS) and microbubbles. In order to better identify the underlying mechanism responsible for BBB opening as well as associated safety, the in vivo noninvasive and transcranial cavitation detection associated with FUS-induced BBB opening was studied. A cylindrically...
Delivery of therapeutic compounds to the brain is limited, because due to their molecular size they cannot cross the blood-brain barrier (BBB). Focused ultrasound (FUS) after administration of microbubbles into the blood-stream has been shown to open the BBB locally, non-invasively and reversibly. In this study, we investigated the time required for BBB's permeability at the sonicated region to revert...
The exact mechanism behind the blood-brain barrier (BBB) opening using Focused Ultrasound (FUS) and microbubbles remains unknown. Here, the effects of the murine skull on the pressure threshold of inertial cavitation were investigated using a passive cavitation detector (PCD) in conjunction with B-mode imaging. A cylindrical vessel with a 610-??m diameter inside a polyacrylamide gel was generated...
Current treatments of neurological and neurodegenerative diseases are limited due to the lack of a truly noninvasive, transient, and regionally selective brain drug delivery method. The brain is particularly difficult to deliver drugs to because of the blood-brain barrier (BBB). Over the past few years, we have been developing methods that combine Focused Ultrasound (FUS) and microbubbles in order...
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