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Successful efforts to control infectious diseases have often required the use of effective vaccines. The current global strategy for control of malaria, including elimination and eradication will also benefit from the development of an effective vaccine that interrupts malaria transmission. To this end, a vaccine that disrupts malaria transmission within the mosquito host has been investigated for...
Region II of the erythrocyte-binding antigen (EBA-175 RII) has been identified as a promising target for a malaria vaccine. A systematic approach to identify optimal preformulation conditions of a non-glycosylated (NG) antigen, EBA-175 RII-NG, has been developed. This approach consists of development of an empirical temperature/pH phase diagram, high throughput stabilizer screening and aluminum salt...
The production, purification and characterisation of recombinant gp140 oligomeric envelope glycoproteins derived from six primary isolates of HIV-1 (covering clades A, B, C, D, F and O) are described. Using a Chinese hamster ovary cell expression system, expression levels of between 0.1 and 1mg/l cell-conditioned culture media were obtained, and purified to >95% by affinity chromatography. A, B,...
Rubella antibody (IgG) has been measured in females reporting for antenatal screening using single radial haemolysis (SRH) and time-resolved fluorescence immunoassay (TRFIA). We have shown TRFIA to be a simple, specific, highly sensitive, quantitative assay for rubella IgG with a lower limit of detection of 0.2IU/ml. Out of 506 sera tested by SRH, 18 (3.6%) had low levels of antibody (<15IU/ml)...
The immunity profile of the English and Welsh population to diphtheria and tetanus has been determined by measuring diphtheria and tetanus antitoxin levels for 3088 and 3142 sera, respectively. Time-resolved fluorimetric immunoassay — DELFIA was used to measure diphtheria antitoxin levels and an in-house, indirect ELISA to measure tetanus antitoxin levels. More than 80% of those aged between 2 and...
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