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The prolongation of action potential duration (APD) is usually related to conditions of low repolarization reserve and leads to long QT syndrome. In these situations, an unbalance between currents can fire early after depolarizations (EADs). This repolarizing disorder has been observed in heart failure situations, where the late sodium current (INaL) has an important role. In this work we evaluate...
The aim of this study was to investigate interactions between acquired long QT syndrome by dofetilide and reduced repolarization reserve in simulated human ventricular cells using prolongation of APD and triangulation of action potential. A Markovian model of hERG capable of reproducing a wild type as well an acquired long QT syndrome by dofetilide was developed and was included into a ventricular...
Computer simulations have been used to study the mechanisms of postrepolarization refractoriness in cardiac cells under ischemic conditions at the cellular level. The ten Tusscher model of the cardiac action potential has been used with the formulation of the ATP-sensitive K+ current by Ferrero et al being adopted. Cells were subjected to hyperkalemia, hypoxic and acidic conditions. The results show...
During the acute phase of myocardial ischemia, electrophysiological changes and heterogeneities predispose the heart to arrhythmogenic reentrant excitation. In this computational work we analyze the role of dispersion of refractoriness on reentry generation in a two-dimensional sheet of ischemic tissue at different stages after the onset of ischemia. A realistic model of regional ischemia was used...
It is well known that ventricular fibrillation (VF) is a major cause of sudden cardiac death in developed countries. Myocardial regional acute ischemia constitutes a heterogeneous substrate which tends to destabilize the electrical depolarizing wave front, thus favouring VF. Functional re-entry in the transmural wall has been hypothesized as the underlying mechanism of VF. In this work, we have theoretically...
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