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Traditionally, VF has been directly related to dispersion of refractoriness. However, further theoretical studies relating refractoriness and reentry generation would be helpful to understand their implication. Recently, the safety factor for conduction (SF) has been proposed as a useful parameter to analyze propagation of action potential (AP) and conduction block. In this work, the relative role...
Ventricular tachycardia and ventricular fibrillation are known to be two types of cardiac arrhythmias that usually take place during acute ischemia and frequently lead to sudden death. In this work, we have studied the different patterns of activation displayed in a virtual ventricular slab preparation after premature stimulation during acute ischemia. Furthermore, we also have analyzed the vulnerable...
It is well known that ventricular fibrillation (VF) is a major cause of sudden cardiac death in developed countries. Myocardial regional acute ischemia constitutes a heterogeneous substrate which tends to destabilize the electrical depolarizing wave front, thus favouring VF. Functional re-entry in the transmural wall has been hypothesized as the underlying mechanism of VF. In this work, we have theoretically...
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