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Torsades de pointes (TdP) is a life-threatening ventricular tachycardia associated to reduction of the rapid delayed rectifier potassium current (IKr) and prolongation of ventricular action potential duration (APD) and long QT (LQT) syndrome. An abnormal increase of the late sodium current (INaL) is also associated to susceptibility to TdP. In this work, a mathematical model of INaL has been proposed...
Computer simulations have been used to study the mechanisms of postrepolarization refractoriness in cardiac cells under ischemic conditions at the cellular level. The ten Tusscher model of the cardiac action potential has been used with the formulation of the ATP-sensitive K+ current by Ferrero et al being adopted. Cells were subjected to hyperkalemia, hypoxic and acidic conditions. The results show...
In this work, we have studied the changes that acute myocardial ischemia exerts in our formulation of the safety factor of conduction (SFm) which consists on a modification of the SF proposed by Shaw and Rudy. Specifically, the effect of each component of ischemia (hyperkalemia, hypoxia and acidosis) was studied separately, and also the evolution of the SFm after the onset of ischemia was obtained...
Tobacco plants (Nicotiana tabacum L. cv. Sevilla) were grown under controlled conditions. The leaf content of Ca2+, Mg2+ and K+, and the activity of the pyruvate kinase were analyzed. The increased application of Ca2+ diminished the content of K+ and Mg2+ in leaves, and decreased the activity of pyruvate kinase. Taking into account these results, we suggest the pyruvate kinase activity as an bioindicator...
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