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Computer simulations have been used to study the mechanisms of postrepolarization refractoriness in cardiac cells under ischemic conditions at the cellular level. The ten Tusscher model of the cardiac action potential has been used with the formulation of the ATP-sensitive K+ current by Ferrero et al being adopted. Cells were subjected to hyperkalemia, hypoxic and acidic conditions. The results show...
Traditionally, VF has been directly related to dispersion of refractoriness. However, further theoretical studies relating refractoriness and reentry generation would be helpful to understand their implication. Recently, the safety factor for conduction (SF) has been proposed as a useful parameter to analyze propagation of action potential (AP) and conduction block. In this work, the relative role...
The safety factor (SF) is an indicator of the safeness of electrical conduction in the myocardium. In the present work, the estimation of the SF based on the formulation proposed by Shaw and Rudy (1997) has been extended to 2D (SF-2D) and evaluated. Furthermore, the effect of the increment of extracellular potassium concentration ([K+]o) on the SF-2D of a convex wavefront has also been studied and...
The safety factor (SF) is an indicator of the safeness of electrical conduction in the myocardium. In the present work, we have studied the sensitivity of the SF defined by Shaw and Rudy to the integration interval (II) using computer simulations, and then defined and evaluated a new and simplified method to calculate SF (SFm). Our results reveal that the sensitivity of the SF to the II is negligible...
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