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Experimental studies of pro-arrhythmic mechanisms are scarcely performed in humans due to the limited availability of human cardiomyocytes. Subsequently, extrapolation of animal experimental research to humans is widely extended. Our aim is to systematically compare the ionic mechanisms of the main cellular biomarkers of arrhythmic risk between human and rabbit using computer simulations. For this...
Computer simulations have been used to study the mechanisms of postrepolarization refractoriness in cardiac cells under ischemic conditions at the cellular level. The ten Tusscher model of the cardiac action potential has been used with the formulation of the ATP-sensitive K+ current by Ferrero et al being adopted. Cells were subjected to hyperkalemia, hypoxic and acidic conditions. The results show...
The safety factor (SF) is an indicator of the safeness of electrical conduction in the myocardium. In the present work, the estimation of the SF based on the formulation proposed by Shaw and Rudy (1997) has been extended to 2D (SF-2D) and evaluated. Furthermore, the effect of the increment of extracellular potassium concentration ([K+]o) on the SF-2D of a convex wavefront has also been studied and...
In this work, we have studied the changes that acute myocardial ischemia exerts in our formulation of the safety factor of conduction (SFm) which consists on a modification of the SF proposed by Shaw and Rudy. Specifically, the effect of each component of ischemia (hyperkalemia, hypoxia and acidosis) was studied separately, and also the evolution of the SFm after the onset of ischemia was obtained...
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