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Carbon‐11 labelled d‐threo‐methylphenidate ([11C]‐(1)), a radiopharmaceutical commonly used to image the dopamine transporter, has been labelled in one step using [11C]‐methyl triflate. No protection of the nitrogen atom on the piperidine ring of d‐threo‐ritalinic acid·HCl was required, as O‐methylation was favored over N‐methylation by performing the methylation in buffered solutions which effectively...
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