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Cytoskeletal proteins such as neurofilaments (NF) and tau are constantly modified by a series of protein kinases and phosphatases. Phosphorylation on the carboxyl-terminal domain of neurofilament subunits, especially NF-H, determines morphology of the NF network and stability of axonal structure. Here, the levels of ERK1 and 2 and cdk5, protein kinases of putative relevance to C-terminal NF phosphorylation...
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