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We review recent progress toward understanding and enhancing the stability of amorphous pharmaceutical solids against crystallization. As organic liquids are cooled to become glasses, fast modes of crystal growth can emerge. One such growth mode, the glass-to-crystal or GC mode, occurs in the bulk, and another exists at the free surface, both leading to crystal growth much faster than predicted by...
Purpose To study the influence of polymer additives on bulk and surface crystal growth in organic glasses (amorphous solids), which are being investigated for delivering poorly soluble drugs and in this role must resist crystallization. Recent studies have discovered new modes of crystal growth that emerge as organic liquids are cooled to form glasses: one existing in the bulk (GC growth) and another...
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